Heinrich-Pette-Institut Leibniz-Institut für Experimentelle Virologie
发明人:
申请号：
EP18199748.7
公开号：
EP3636781A1
申请日:
2018.10.10
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a method for identifying compounds which reverse HIV-1 latency in a subject and can therefore be therapeutically used for eliminating a latent viral reservoir in a subject infected with HIV-1. Further, the present invention relates to a method for identifying compounds which stabilize HIV-1 latency in a subject and can therefore be therapeutically used for preventing replication and outgrowth of latent HIV-1. In yet another aspect, the present invention relates to a compound that increases or decreases the expression level of the HIV-1 Vpu gene for use in method of treating an HIV-1 infection in a subject in need thereof. In yet another aspect, the present invention relates to a compound that increases or decreases the binding between the HIV-1 Vpu protein and NF-κB for use in method of treating an HIV-1 infection in a subject in need thereof.
