KAMADA MAKOTO JAPAN,SEKIGUCHI GAKU JAPAN,KIDOKORO MOTONORI JAPAN
申请号：
IN1865/MUMNP/2012
公开号：
IN2012MN01865A
申请日:
2012.07.30
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
There have been demands for a pharmaceutical composition which has good dissolvability and contains a compound represented by formula (I) a pharmaceutically acceptable salt thereof or a solvate of the compound or salt and which has an inhibitory effect on activated blood coagulation factor X and is useful as a prophylactic and/or therapeutic agent for thrombotic diseases. Disclosed is a method for producing a pharmaceutical composition that contains a compound represented by formula (I) which comprises a step wherein a compound represented by formula (I) a pharmaceutically acceptable salt thereof or a solvate of the compound or salt one or more excipients selected from the group consisting of sugar alcohols and water-swellable additives a disintegrant and a binder are mixed under such conditions that the maximum water content in a granulated product is maintained at 10% or less during the granulation.
