The invention provides methods of improving and/or preventing one or more depression-like symptoms by administering to an individual an effective amount of calcium L-threonate or a hydrate thereof. Also provided are related kits and articles of manufacture.本發明提供藉由向個體投與有效量之L-蘇糖酸鈣或其水合物而改善及/或預防一或多種類抑鬱症狀之方法。亦提供相關套組及製造物件。