CAI, ZHENWEI,KONTEATIS, ZENON D.,ZHOU, DING,TRAVINS, JEREMY M.,ZAHLER, ROBERT,POPOVICI-MULLER, JANETA
申请号：
PE0000392016
公开号：
PE05242016A1
申请日:
2014.07.10
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Provided are compounds of formula (i) useful for the treatment of cancer. Where: a ring is nonociclico X is aryl, etc. etc. n, R1, R3, R4 and R6, R7 and R8 are Hydrogen, etc. are Hydrogen or alkyl of C1 - C6.Preferred compounds are: N2 - (3,3 - difluorociclopentil) - N4 - (3,5-difluorophenyl) - 6 - (4 - (trifluoromethyl) thiazol-2-yl) - 1,3,5-triazine-2,4-diamine N2 - (3,3 - difluorociclobutil) - N4 - (3,5-difluorophenyl) - 6 - (4) - (trifluoromethyl) thiazol-2-yl) - 1,3,5-triazine-2,4-diamineSe proporcionan compuestos de formula (I) utiles para el tratamiento de cancer. Donde: anillo A es arilo nonociclico, etc. X es N, etc. R1, R3, R4 y R6 son hidrogeno, etc. R7 y R8 son hidrogeno o alquilo C1-C6. Son compuestos preferidos: N2-(3,3-difluorociclopentil)-N4-(3,5-difluorofenil)-6-(4-(trifluorometil)tiazol-2-il)-1,3,5-triazina-2,4-diamina N2-(3,3-difluorociclobutil)-n4-()3,5-difluorofenil)-6-(4-(trifluorometil)tiazol-2-il)-1,3,5-triazina-2,4-diamina
