Compound of formula (I): ** Formula ** which includes its cyclic isomers having the formula ** Formula ** its stereoisomers, its solvates, its hydrates and its pharmaceutically acceptable salts, in which: n is 1； X is CH2； Z is H； R1 and R2 independently or together are -OH； a hydroxyl bearing a protecting group of boronic acid； or a group that can be hydrolyzed to a hydroxyl group in an aqueous solution at physiological pH or in biological liquids； R3 and R4 are hydrogen and R5 is: ** Formula ** in which R20 is hydrogen, (C1-8) alkyl, (C1-6) alkylcarbonyl, dialkyl (C1-6) aminocarbonyl, cycloalkyl (C3-8) carbonyl； benzyl, benzoyl, (C 1-6) alkyl oxycarbonyl, aralkyloxycarbonyl, pyridinyl, pyrimidinyl, phenyl, thiazolyl substituted phenyl, phenylaminocarbonyl, alkylsulfonyl or phenylsulfonyl； wherein the benzyl, benzoyl, pyridinyl, pyrimidinyl, phenyl, phenylaminocarbonyl, alkylsulfonyl and phenylsulfonyl groups are optionally monosubstituted or independently disubstituted with R12； R12 is halogen, trifluoromethyl, cyano, nitro, (C1-6) alkyl, alkoxy (C1-6), cycloalkyl, carboxy, acetamido, hydroxy, hydroxyalkyl (C1-6), hydroxymethyl, trifluoromethoxy, sulfamoyl, carbamoyl, sulfonamido, alkylsulfonyl , phenylsulfonyl, aryl, or heteroaryl； wherein the aryl and heteroaryl groups are optionally monosubstituted or independently plurisubstituted with R7； R7 is halogen, (C1-10) alkyl, (C1-10) alkoxy, (C1-10) alkyl, amino, dialkyl (C1-10) amino, benzyl, benzyloxy, hydroxyalkyl (C1-6), hydroxymethyl, nitro, trifluoromethyl , trifluoromethoxy, trifluoromethylthio, N-hydroxyamino, cyano, carboxy, acetamido, hydroxy, sulfamoyl, sulfonamido, carbamoylCompuesto de fórmula (I):**Fórmula** que incluye sus isómeros cíclicos que presentan la fórmula**Fórmula** sus estereoisómeros, sus solvatos, sus hidratos y sus sales farmacéuticamente aceptables, en la que: n es 1； X es CH2； Z es H； R1 y R2 independiente o conjuntamente son -OH； un hidroxilo portador de un grupo protector de ácido 20
