MICHAEL S. HERSHFIELD,SUSAN J. KELLY,MERRY R. SHERMAN,MARK G. P. SAIFER,DAVID L. WILLIAMS
申请号：
PT10180428
公开号：
PT2305819E
申请日:
2001.02.07
申请国别(地区):
PT
年份:
2015
代理人:
摘要：
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer such that the bioactivity of the protein is essentially retained in the conjugate. Such conjugates are unusually well suited for treatment of chronic conditions because they are less likely to induce the formation of antibodies and/or accelerated clearance than are similar conjugates prepared from protein preparations containing traces of large aggregates.
