Disclosed are 5,7-dimethoxy-2-phenyl-4-oxo-3,4-dihydroquinazolines and analogues thereof or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof, wherein: Q is selected from CR12 and nitrogen； V is selected from CH and nitrogen； U is C=O； -X-(Z)n-G is selected from 1-[(dimethylamino)carbonyl]piperidin-4-yloxy, 1-acetylpiperidin-4-yloxy, 2-(isoindolin-2-yl)ethoxy, (4-acetylpiperazin-1-yl)ethoxy, (1H-imidazol-1-yl)ethoxy, (piperidin-1-yl)ethoxy, 2-(1-isopropyl-2,4-dioxo-imidazolidin-3-yl)-ethoxy, 2-(5-phenyl-2,4-dioxo-imidazolidin-3-yl)-ethoxy, (2,4-dioxo-imidazolidin-3-yl)methyl, 2-(azepan-1-yl)ethoxy, 2-(azetidin-1-yl)ethoxy, 2-(3-(acetylamino)-azetidin-1-yl)ethoxy, (5-oxopyrrolidin-2-yl)methoxy, [4-{ acetyl(isopropyl)amino} piperidin-1-yl]methyl, (4-(isopropylamino)piperidin-1-yl)methyl, 2-(2,5-dioxo-pyrrolidin-1-yl)ethoxy and (1H-tetrazol-5-yl)methyl； R12 is selected from hydrogen, alkoxy, and halogen； Rc is selected from hydrogen and (pyrrolidin-1-yl)propyl； Ra1, Ra2, and Ra3 are independently selected from hydrogen, alkyl, alkoxy, halogen, and heterocycle； Rb2 and Rb6 are hydrogen； and Rb3 and Rb5 are independently selected from hydrogen and alkyl； provided that at least one of Ra1, Ra2, and Ra3 is not hydrogen； if Ra2 or Ra3 is chloro, then Ra1 is not hydrogen； with at least one proviso selected from: Rc is not hydrogen； Rb3 is hydrogen； V is not N； and X-(Z)n is not ethoxy. Representative compounds include 4-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)-N,N-dimethylpiperidine-1-carboxamide； 2-(4-(1-acetylpiperidin-4-yloxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one； 3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzyl)imidazolidine-2,4-dione； (S)-2-(3,5-dimethyl-4-((5-oxopyrrolidin-2-yl)methoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one； N-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)benzyl)piperidin-4-yl)-N-isopropylacetamide； 2-(4-((4-(isopropylamino)piperidin-1-yl)methyl)phenyl)-5,7-dimethoxyquinazolin-4(
