atropisomers of 2-purinyl-3-tolyl-quinazolinones derivatives and methods of use

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专利权人:

GILEAD CALISTOGA LLC

发明人:

JERRY B. EVARTS,ROGER G. ULRICH

申请号：

BRPI1012333

公开号：

BRPI1012333A2

申请日:

2010.03.24

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

The invention provides compounds, compositions and methods to treat certain inflammatory conditions and/or oncology by administering a compound that inhibits PI3K isoforms, particularly the delta isoform. It further provides specific stereoisomers of a compound useful for these methods. In particular, the compound is an optically active atropisomer of 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/