A medical device includes a surgical needle and an elongated suture. The suture has a first end attached to the surgical needle and a second end located away from the surgical needle. The suture includes a mesh wall and a plurality of pores extending through the mesh wall. At least some of the pores in the macroporous size range of greater than 200 microns and adapted to facilitate tissue integration through the mesh wall of the suture when introduced into a body. The suture is configured to resist a tensile load applied along an axial direction between the first and second ends of the elongated suture such that upon overloading the mesh wall collapses upon itself resulting in apparent suture elongation, collapsed diameter, and/or reduction in pore size.