TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES
发明人:
Zhongwei NIU,Shidong JIANG
申请号：
US16629881
公开号：
US20200181292A1
申请日:
2018.05.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed is a novel water-soluble natural polysaccharide antibacterial material. The molecules of the novel water-soluble natural polysaccharide antibacterial material not only contain guanidyl, but also contain amino acid groups, so that the biosafety of material is taken into consideration while the antibacterial performance of chitosan is improved, and the novel water-soluble natural polysaccharide antibacterial material has a low cytotoxicity and is a green antibacterial product. Also disclosed is a method for preparing the above-mentioned material, comprising the steps of: 1) dissolving chitosan in a diluted acid solution to obtain a diluted acid aqueous solution of chitosan； 2) adding cyanamide or dicyandiamide into the diluted acid aqueous solution of chitosan obtained in step 1) for reaction； 3) adding an amino acid activation solution into the reaction system in the step 2) for amidation； 4) adding hydroxylamine hydrochloride to terminate the reaction； and 5) filtering the reaction solution and then dialyzing the solution with deionized water, and performing microwave vacuum-drying to obtain the novel water-soluble natural polysaccharide antibacterial material. The method can be performed in a reaction kettle in a single-reaction manner, and the used primary raw materials are rich in sources and low in price, and are suitable for industrial production.
