Tao ZHU,Lei DUAN,Mingming YANG,Zhongqi SHAO,Xuefeng YU,Helen Huihua MAO,Dongxu QIU
申请号：
US15582400
公开号：
US20180296660A1
申请日:
2017.04.28
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides an immunogenic composition for preventing pneumococcal diseases, comprising PspA-MRXI, PspA-EF5668, PspA-EF3296 and PlyL460D, wherein the amount of each component is 10-100 μg/ml the immunogenic composition is prepared by adding to aluminum adjuvant the corresponding dosages of the four stock solutions PspA-mRXI, PspA-EF5668, PspA-EF3296 and PlyL460D, and mixing them homogeneously the immunogenic composition can prevent infection and invasion by Streptococcus pneumonia, covering more than 95% of the strains in clinic. The immunogenic composition has a wide application in the prevention of pneumonia, and is suitable for large-scale production in industry for its simple preparation method, low production cost, and short production cycle.
