Kyungpook National University Industry-Academic Cooperation Foundation
发明人:
Young Mo Kang,In San Kim,Jin Hee Kang,Keum Hee Sa
申请号：
US13907327
公开号：
US09605038B2
申请日:
2013.05.31
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a fusion peptide comprising dhFas-1 domain and MMP substrate and use thereof. More specifically, the present invention relates to a fusion peptide, comprising a) a dhFas-1 domain which is the fourth fas-1 domain of βig-h3 lacking H1 and H2 regions； b) a MMP (Matrix metalloproteinase) substrate； and c) a peptide comprising RGD motif and an use thereof for preventing and treating inflammatory disease. The fusion peptide of the present invention inhibits expension of rheumatoid arthritis by adhesion and migration of sinoviocytes and may be used for preventing or treating inflammatory disease by inhibiting infiltration of immune cells.
