The invention is related to peptide constructs, i.e., polypeptides obtained by linking together two or more peptides based on or derived from different molecules, which are useful in the treatment or prevention of autoimmune diseases, specifically rheumatiod arthritis (RA) and compositions containing same, methods for producing same and methods for using same wherein the peptide constructs have the formula P1-X-P2 where PI is a peptide associated with autoimmune disease P2 is a peptide which will cause a Th2 directed immune response and X is a direct bond or linker for covalently bonding P1 and P2.
