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Carbinol derivatives having heterocyclic linker
专利权人:
Sumiko Kurobuchi;Hisashi Sumida;Yuichiro Watanabe;Kimiyuki Shibuya;Minoru Koura;Takashi Enomoto;Takayuki Matsuda
发明人:
Minoru Koura,Hisashi Sumida,Sayaka Kurobuchi,Takayuki Matsuda,Yuichiro Watanabe,Takashi Enomoto,Kimiyuki Shibuya
申请号:
US12769104
公开号:
US08551985B2
申请日:
2010.04.28
申请国别(地区):
US
年份:
2013
代理人:
摘要:
[Object]It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means]A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate:(wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)
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