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SUBSTITUTED CARBINOL COMPOUND HAVING CYCLIC LINKER
专利权人:
LTD.;KOWA COMPANY
发明人:
YAMAGUCHI, YUKI,KOURA, MINORU,KUROBUCHI, SAYAKA,MATSUDA, TAKAYUKI,OKUDA, AYUMU,SUMIDA, HISASHI,WATANABE, YUICHIRO,ENOMOTO, TAKASHI,SHIBUYA, KIMIYUKI
申请号:
NZ58950409
公开号:
NZ589504A
申请日:
2009.05.29
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed herein is a carbinol compound of formula (I), (for example 5-(benzo[d][1,3]dioxol-5-yl)-3-(2-(5-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-propylphenoxy)pyridin-2-yl)-2-oxoethyl)-5-methylimidazolidine-2,4-dione) wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are Liver X receptor (LXR) agonists and are therefore useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.
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中国工程科技知识中心
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