A method of determining a responsiveness of a patient having brain state changes, comprising receiving an indication of a triggering event administering to the patient, in response to the indication, a test of responsiveness determining, based upon a result of the test, at least one responsiveness parameter selected from the group consisting of (i) a time of occurrence of a change in the patients responsiveness, (ii) a duration of a change in the patients responsiveness (iii) a magnitude of a change in the patients responsiveness, (iv) a time interval from the indication of event occurrence to a change in the patients responsiveness, (v) a type of change in the patients responsiveness, (vi) an estimation of a seizure severity (vii) a classification of a seizure into clinical or subclinical (viii) a classification of a clinical seizure into simple partial, complex partial, or generalized (ix) an assessment of efficacy of a therapy for the patients medical condition (x) an assessment of the state of the disease and formulation of a prognosis for the patient (xi) an estimation of a risk of injury or death for the patient and (xii) two or more thereof. A medical device system capable of implementing the method.