SWIDORSKI, JACOB,MEANWELL, NICHOLAS A.,REGUEIRO-REN, ALICIA,SIT, SING-YUEN,CHEN, JIE,CHEN, YAN
申请号：
SG11201404748X
公开号：
SG11201404748XA
申请日:
2013.02.13
申请国别(地区):
SG
年份:
2014
代理人:
摘要：
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.
