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C-3 CYCLOALKENYL TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY
专利权人:
Bristol-Myers Squibb Company
发明人:
Jacob Swidorski,Nicholas A. Meanwell,Alicia Regueiro-Ren,Sing-Yuen Sit,Jie Chen,Yan Chen
申请号:
US13760726
公开号:
US20130210787A1
申请日:
2013.02.06
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV:wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.
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来源网址:
http://www.ckcest.cn/home/

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