Phosphodiesterase 1-target tracer and method

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专利权人:

イントラ-セルラー・セラピーズ・インコーポレイテッド;イントラ－セルラー・セラピーズ・インコーポレイテッド

发明人:

リ・ペン,ローレンス・ピー・ウェノグル,ジャオ・ジュン,ジェン・ハイリン

申请号：

JP2015254522

公开号：

JP6224063B2

申请日:

2015.12.25

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

Tracers targeting phosphodiesterase 1 for use in gamma radiation detection-based diagnostic techniques, particularly gamma-emitter labeled tracers for SPECT and positron emitter-labeled compositions for PET are disclosed. Radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, biomarkers for phosphodiesterase 1 [PDE1) in vivo, methods for developing novel therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), Central Nervous System (CNS) and Cardiovascular (CV) disorders, and methods of detection and treatment are also disclosed.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/