PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS

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专利权人:

INTRA-CELLULAR THERAPIES; INC.

发明人:

LI, PENG,WENNOGLE, LAWRENCE, P.,ZHAO, JUN,ZHENG, HAILIN

申请号：

EP10822355

公开号：

EP2485771A4

申请日:

2010.10.07

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Tracers targeting phosphodiesterase 1 for use in gamma radiation detection-based diagnostic techniques, particularly gamma-emitter labeled tracers for SPECT and positron emitter-labeled compositions for PET are disclosed. Radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, biomarkers for phosphodiesterase 1 [PDE1) in vivo, methods for developing novel therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), Central Nervous System (CNS) and Cardiovascular (CV) disorders, and methods of detection and treatment are also disclosed.

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