An apparatus for cleaning and sterilizing an interior of a shoe which generates ultrasonic wind of a whirlwind type in the interior of the shoe to remove foreign substances from the interior of the shoe and which injects ultra fine particles of solution into the interior of the shoe to sterilize the interior of the shoe. The apparatus includes a housing opened or closed with a door a shoe supporting member mounted on a top end of a support pillar having a predetermined length and vertically installed in an inner space of the housing, wherein the show supporting member is configured to be inside the shoe and support the shoe by hanging the shoe thereto a vibration guide pipe fixed to an inside of the shoe supporting member and a nozzle tube movably installed in the vibration guide pipe.
