Annegret Preuss,Arno Whiehe,Beate Röder,Hagen Von Briesen,Karin Löw,Klaus Langer,Susanna Gräfe,Sylvia Wagner,Thomas Knobloch,Volker Albrecht
申请号：
BR112012013951
公开号：
BR112012013951A2
申请日:
2010.12.08
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
pharmaceutical formulation of nanoparticles and their preparation methods and uses. compositions, which are storage stable, and a method of producing pharmaceutical-based nanoparticle formulations for clinical use in photodynamic therapy comprising a hydrophobic photosensitizer, poly (lactic-co-glycolic) acid and stabilizing agents are provided. These nanoparticle pharmaceutical formulations provide therapeutically effective amounts of photosensitizer for parenteral administration. In particular, tetrapyrrole derivatives may be used as photosensitizers, the efficacy and safety of which are enhanced by such nanoparticle formulations. The method of preparing plga-based nanoparticles under sterile conditions is also taught. In one preferred embodiment of the present invention, plga-based nanoparticles have an average particle size of less than 500 nm and the photosensitizer is temoporphine, 5,10,15,20-tetrakis (3-hydroxyphenyl) chlorine (mthpc). In another embodiment, the 2,3-dihydroxy-5,10,15,20-tetrakis (3-hydroxyphenyl) chlorine (mthpd-oh) photosensitizer is formulated as a nanoparticle for parenteral administration. however, in another preferred embodiment, the photosensitizer is 5,10,15,20-tetrakis (3-hydroxyphenyl) porphyrin (mthhp). The formulations may be used for the treatment of hyperplastic and neoplastic conditions, inflammatory problems, and more specifically for targeting tumor cells.formulação farmacêutica de nanopartículas e respectivos métodos de preparação e usos. composições, que são estáveis em armazenagem, e um método de produção de formulações de nanopartículas de base farmacêutica para uso clínico em terapia fotodinâmica compreendendo um fotossensibilizador hidrofóbico, ácido poli(láctico-co-glicólico) e agentes estabilizadores são fornecidos. estas formulações farmacêuticas de nanopartículas fornecem quantidades terapeuticamente eficazes de fotossensibilizador para administração parenteral. em particular, derivados de tetrapirrole podem ser usad
