Annegret Pruess,Arno Wiehe,Beate Röder,Hangen Von Briesen,Klaus Langer,Matthias Wacker,Susanna Gräfe,Sylvia Wagner,Volker Albrecht
申请号：
BR112012013952
公开号：
BR112012013952A2
申请日:
2010.12.08
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
pharmaceutical formulation of nanoparticles and their preparation methods and uses. The compositions, which are storage stable, and a pharmaceutical based production method of nanoparticutate formulations for clinical use in photodynamic therapy comprising a hydrophobic photosensitizer, poly (lactic-co-glycolic acid) and stabilizing agents are provided. These nanoparticulate pharmaceutical formulations provide therapeutically effective amounts of photosensitizers, the effectiveness and safety of which are enhanced by nanoparticles such as the formulations. It also leaches the method of preparing sterile nanoparticle based plga in one of the preferred embodiments of the present invention Sterile nanoparticle based plga in one of the preferred embodiments of the present invention nanoparticle based plga have a lower average particle size than 500 nm and the photosensitizer is temoporffn, 5,10,15,20-tetrakis (3-hydroxyphenyl) chlorine (mthpc). In another embodiment, the 2,3-dihydroxy 5,10,15,20-tetrakis (3-hydroxyphenyl) chlorine (mthpd-oh) photosensitizer is formulated with a nanoparticle for parenteral administration. however, in another preferred photosensitizing embodiment is 5,10,15,20-tetrakis (3-hydroxyphenyl) porphyrin (mthpp). The formulations may be used for treating hyperptasic and neoplastic conditions, inflammatory problems and more specifically to target tumor cells.formulação farmacêutica de nanopartículas e respectivos métodos de preparação e usos. as composições, que são estáveis em armazenagem, e um método de produção de base farmacêutica nanoparticutate formulações para uso clínico no fotodinâmica terapia compreendendo um fotossensibilizador hidrofóbico, poli (ácido láctico-co-glicólico) e agentes estabilizadores são fornecidos. estas formulações farmacêuticas nanoparticulados fornecer terapeuticamente quantidades eficazes de fotossensibilizadores, cujo eficácia e segurança são reforçadas por nanopartículas, tais as formulações. ele também lixivia o
