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MODIFIED PRODRUG FORMS OF AP/AMP
专利权人:
VION PHARMACEUTICALS; INC.
发明人:
DOYLE, TERRENCE W.,KARRA, SRINIVASA,LI, ZUJIN,LIN, XU,MAO, JOHN,QIAO, QI,XU, YANG
申请号:
CA2423220
公开号:
CA2423220C
申请日:
2001.10.15
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention relates to compounds according to the structure offollowing formula (I), where R is H or CH3 R2 is phosphate which can be freeacid or salt R3 is H, F, C1, Br, I, OCH3, OCF3, CF3 or a C1-C3 alkyl groupR4 is H, F, C1, Br, I, OCH3, OCF3 or CF3 and R5 and R6 are each independentlyH, F, C1, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3,R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H whichmay be used to treat neoplasia, including cancer.
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