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3,4-DIHIDROPOLO[1,2-A]PIRAZIN-2,8(1H)-DIKARBOKSAMIDO DARINIAI, JŲ GAMYBA IR TERAPINIS PANAUDOJIMAS
专利权人:
SANOFI
发明人:
COTE-DES-COMBES, Sylvain,FROISSANT, Jacques,GIBERT, Jean-Francois,MARGUET, Frank,PACAUD, Christophe,PUECH, Frédéric,RAVET, Antoine
申请号:
LT11781590
公开号:
LT2588480T
申请日:
2011.06.01
申请国别(地区):
LT
年份:
2016
代理人:
摘要:
Compounds corresponding to the general formula (I) wherein R2 represents a group C1-10-alkyl, C3-10-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyl-C3-7-cycloalkyl, C3-7-cycloalkyl-C3-7-cycloalkyl, C1-6-alkylthio-C-1-10-alkyl, C1-6-alkoxy-C1-10-alkyl, hydroxy-C1-10-alkyl, hydroxy-C1-6-alkyl-C3-7-cycloalkyl-C1-6-alkyl, hydroxy-C3-10-cycloalkyl, C1-10-fluoroalkyl or C3-10-fluorocycloalkyl; an optionally substituted heterocyclic group; a group C1-10-alkyl substituted with an optionally substituted heterocyclic group; X6 represents a group chosen from hydrogen, fluorine, chlorine and bromine atoms or a group C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-fluoroalkyl or cyano; and R7 represents an aryl group such as phenyl or naphthyl, optionally substituted with one or more substituents, in the form of the base or of an acid-addition salt, and the therapeutic use thereof.
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