The invention discloses an automatic blood pressure measurement device. The automatic blood pressure measurement device comprises a supporting shell, a sleeve, an air bag cuff, a tightening mechanism and a tightening motor. The automatic blood pressure measurement device is characterized in that the tightening mechanism comprises a supporting frame, a driving shaft and a driven shaft, the driving shaft is located on one side of the air bag cuff and is installed in the supporting frame in the mode that the driving shaft stretches across the air bag cuff, one end of the driving shaft is connected with the tightening motor, the driven shaft is located on the other side of the air bag cuff and is installed in the supporting frame in the mode that the driven shaft stretches across the air bag cuff and is opposite to the driving shaft, the driving shaft and the driven shaft can move relatively so as to clamp the air bag cuff, and in this way, the air bag cuff can be tightened or move in the relaxing and returning direction through rotation of the driving shaft. According to the automatic blood pressure measurement device, unidirectional pressure exerted on a measured limb can be greatly reduced, and the measurement precision of the automatic blood pressure measurement device is improved in addition, the structure of the device is optimized, and production and maintenance of the device are facilitated.