The invention relates to a surgical instrument comprising:—a distal tool (5) securely fastened to a distal end of a rotation shaft (4) and rotatably mounted on and in the extension of a distal member (30) rotatably mounted at an end of an elongated arm (3),—an comprising motorized means (20) for actuating the distal motion of the distal tool (5) and further comprising controlling means (21) for a user to control the motorized means (20)—a handle (1) extending from the actuation unit (2) and comprising a lever (11) mechanically coupled to the distal tool (5) for actuation of said distal tool (5) characterized in that the handle (1) has a non-axially-symmetric shape and is mounted on and in the extension of the actuation unit (2) with coupling means (12, 22) enabling rotation of the handle (1) relative to the actuation unit (2) around the longitudinal axis, and wherein the controlling means (21) are adapted to be operated by the user whatever the rotational position of the handle (1) relative to the actuation unit (2).
