The present invention provides a diagnosis system for detecting pathological change. The system comprises a medical image database, and a computer device for executing a diagnosis software. The gray level in a medical image or a 3D image of the tested subject and the data from the medical image database are compared by the computer device to accurately and swiftly determine whether the tested subject is sick or not or the degree of the disease.本創作提供一種病變程度判斷系統,該系統包括一醫學影像資料庫及一用以執行一病變判讀軟體之電腦裝置。該電腦裝置將一待測個體的醫學影像檔的灰階值或三維影像與該醫學影像資料庫中的數據比對,以精準快速地判斷該待測個體是否患病或判斷病變程度。