BARRIL-ALONSO XAVIER,DYMOCK BRIAN WILLIAM,DRYSDALE MARTIN JAMES,JORDAN ALLAN,FROMONT CHRISTOFE
申请号：
IN1046/CHENP/2006
公开号：
IN254955B
申请日:
2006.03.27
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
Compounds of formula (I) are inhibitors of HSP90 activity in vitro or in vivo, and of use in the treatment of inter alia, cancer: (I) wherein R2 is a group of formula -(Ar1)m-(Alk1)p-(Z)r(Alk2)s-Q wherein Ar1 is an optionally substituted aryl or heteroaryl radical, Alk1 and Alk2 are optionally substituted divalent C1-C3 alkylene or C2-C3alkenylene radicals, m, p, r and s are independently 0 or 1, Z is -O-, -S-, -(C=O)-, -(C=S)-, -SO2-, -C(=O)O-, -C(=O)NRA-, -C(=S)NRA-, -SO2NRA-,-NRAC(=O)-,-NRASO2- or-NRA-wherein RA is hydrogen or Ci-Ce alkyl, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical R3 is hydrogen, an optional substituent, or an optionally substituted (C1-C6)alkyl, aryl or heteroaryl radical and R4 is a carboxylic ester, carboxamide or sulfonamide group.
