A tablet cassette is provided that can easily adjust the tablet separating position depending on the size of a table to be dispensed. The tablet cassette includes a plurality of tablet holding members that is rotatable together with the rotor and is elastically deformable so as to enter the table guide groove from an opening end thereof and to press a table in the table guide groove, the plurality of table holding members being provided corresponding to the plurality of tablet guide grooves; and a pressing member that is mounted on the cassette body and presses the table holding member toward the table guide groove when the table guide groove is located at a position corresponding to a tablet outlet provided in the cassette body.