A tablet cassette is provided that can easily adjust the tablet separating position depending on the size of a tablet to be dispensed. The tablet cassette includes a plurality of tablet holding members that is rotatable together with the rotor and is elastically deformable so as to enter the tablet guide groove from an opening end thereof and to press a tablet in the tablet guide groove, the plurality of tablet holding members being provided corresponding to the plurality of tablet guide grooves； and a pressing member that is mounted on the cassette body and presses the tablet holding member toward the tablet guide groove when the tablet guide groove is located at a position corresponding to a tablet outlet provided in the cassette body.
