苯、吡啶及噠嗪衍生物农业专利-农业学术服务平台

发明人:: HUANG, KENNETH HE,黄元河,黃元河,EAVES, JERON,杰伦　伊华司,傑倫　伊華司,HANSON, GUNNAR,格纳　韩森,格納　韓森,VEAL, JAMES,詹母士　维尔,詹母士　維爾,BARTA, THOMAS,汤码士　巴塔,湯碼士　巴塔,GENG, LIFENG,丽芳　简,麗芳　簡,HINKLEY, LINDSAY,林赛　欣克丽,林賽　欣克麗,杰伦伊华司,傑倫伊華司,格纳韩森,格納韓森,詹母士维尔,詹母士維爾,汤码士巴塔,湯碼士巴塔,丽芳简,麗芳簡,林赛欣克丽,林賽欣克麗

摘要：: Disclosed are compounds and pharmaceutically acceptable salts of Formula (I) : wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , n, Q1, Q2, Q3, Y, and X 1 -X 4 are as defined herein. Compounds of Formula (I) are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.本發明揭示式I化合物及其醫藥學上可接受之鹽，其中R1、R2、R3、R4、R5、R6、R7、n、Q1、Q2、Q3、Y及X1－X4係如本文所定義。式I化合物適用於治療與細胞增殖相關之疾病及/或病症，諸如癌症、炎症、關節炎、血管新生或其類似疾病。本發明亦揭示包含本發明化合物之醫藥組合物及使用該等化合物治療上述病症之方法。