A compound according to Formula I: wherein R1, LA, CyA, RA, R2, R3, and R4 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions, pain, neuroinflammatory conditions, neurodegenerative conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, cardiovascular diseases, leukemia, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.本發明揭示一種式I之化合物：其中R1、LA、CyA、RA、R2、R3及R4係如本文所述。本發明係關於拮抗涉及發炎病況之GPR84(一種G蛋白質偶合受體)之如式I之新穎化合物，及用於製備此等新穎化合物之方法，包含此等化合物之醫藥組合物，及藉由投與本發明化合物來預防及/或治療發炎病況、疼痛、神經發炎病況、神經退化性病況、傳染病、自體免疫疾病、內分泌及/或代謝疾病、心血管疾病、白血病、及/或涉及免疫細胞功能受損之疾病的方法。
