A method of using a sleep enhancement medical food to improve human sleep quality. This sleep enhancement medical food consists of transfer factor, lactic acid generating bacteria, and/or glucans in appropriate combinations. The sleep enhancement medical food, administered correctly, reduces cortisol levels. High cortisol causes insomnia. Dosage amounts are adjusted for client weight. Consumption frequency and dosage may be adjusted in response to cortisol measurements. Typically, consumption of the sleep enhancement medical food is done under professional supervision, and may be combined with other treatment strategies.