The Board of Trustees of the Leland Stanford Junior University
发明人:
GRAEF Isabella A.,ALHAMADSHEH Mamoun M.
申请号：
SI201331131
公开号：
SI2934514T1
申请日:
2013.12.18
申请国别(地区):
SI
年份:
2018
代理人:
摘要：
Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.
