HOFMEISTER, LUCAS HUDSON,霍夫麦斯特 卢卡斯 哈德森,霍夫麥斯特 盧卡斯 哈德森,FISCHER, OLIVER MARTIN,费雪 奥利佛 马丁,費雪 奧利佛 馬丁
申请号：
TW108116605
公开号：
TW202015676A
申请日:
2019.05.14
申请国别(地区):
TW
年份:
2020
代理人:
摘要：
The present invention relates to use 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds for the treatment or prophylaxis of diseases which are associated with nerve fiber sensitization, and/or other pathological conditions associated with autonomic imbalance caused by increased chemoreceptor sensitivity, in particular for the treatment of breathing disorders, Cheyne Stokes respiration, central and obstructive sleep apnea, cardiovascular disease, hypertension, resistant hypertension, and heart failure, which are related to increased activity of P2X3 receptors.本發明係關於如本文所闡述及定義之通式(I)之經1,3-噻唑-2-基取代之苯甲醯胺化合物的用途、包含該等化合物之醫藥組合物及組合，其用於治療或預防與神經纖維敏化作用相關疾病及/或其他與由化學受體敏感性增加引起之自主神經失衡相關的病理狀況，具體而言用於治療與P2X3受體之活性增加有關的呼吸障礙、謙史二氏呼吸(Cheyne Stokes respiration)、中樞及阻塞性睡眠呼吸中止、心血管疾病、高血壓、頑固性高血壓及心臟衰竭。
