The invention provides modulators for the orphan nuclear receptor RORγ and methods for treating RORγ mediated diseases by administering these novel RORγ modulators to a human or a mammal in need thereof. Specifically, the present invention provides carboxamide or sulfonamide containing cyclic compounds of Formula (1), (1’), (100), (100’), (200) and (200’) and the enantiomers, diastereomers, tautomers, N-oxides, solvates and pharmaceutically acceptable salts thereof.本發明提供針對孤兒核受體RORγ調節物及藉由將該等新穎RORγ調節物投與有需要的人類或哺乳動物來治療RORγ介導之疾病之方法。特定而言，本發明提供式(1)、(1’)、(100)、(100’)、(200)及(200’)之含有甲醯胺或磺醯胺之環狀化合物及其鏡像異構物、非鏡像異構物、互變異構物、N-氧化物、溶劑合物及醫藥上可接受之鹽。
