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2-PHENYLPYRIMIDINE-4-CARBOXAMIDES AS AHR INHIBITORS
专利权人:
Bayer Aktiengesellschaft;Bayer Pharma Aktiengesellschaft;Deutsches Krebsforschungszentrum
发明人:
Julien LEFRANC,Norbert SCHMEES,Ulrike RÖHN,Ludwig ZORN,Judith GÜNTHER,Ilona GUTCHER,Lars RÖSE,Benjamin BADER,Detlef STÖCKIGT,Michael PLATTEN
申请号:
US16765780
公开号:
US20200283395A1
申请日:
2018.11.16
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention covers 2-phenylpyrimidine-4-carboxamide compounds of general formula (I): (I) 5 in which X, Y, Z, R1, R2, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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