The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which X, R1, R2, R3, R4and R5are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.本發明涵蓋通式(I)之2-雜芳基-3-氧代-2,3-二氫噠嗪-4-甲醯胺化合物:其中X、R1、R2、R3、R4及R5如本文所定義,製備該等化合物之方法、可用於製備該等化合物之中間化合物、包含該等化合物之醫藥組合物及組合,以及該等化合物用於製造醫藥組合物之用途,該等醫藥組合物作為唯一藥劑或與其他活性成分組合用於治療或預防疾病,尤其具有失調的免疫反應之癌症或病況或與異常AHR信號傳導相關之其他病症。