Guangcheng Jiang;Frédérique Menzaghi;Roberta Vezza Alexander;Derek T. Chalmers;Zhiyong Luo;Javier Sueiras-Diaz;Claudio D. Schteingart;Robert H. Spencer
发明人:
Claudio D. Schteingart,Frédérique Menzaghi,Guangcheng Jiang,Roberta Vezza Alexander,Javier Sueiras-Diaz,Robert H. Spencer,Derek T. Chalmers,Zhiyong Luo
申请号：
US12773992
公开号：
US08486894B2
申请日:
2010.05.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention relates to synthetic peptide amides that are ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure:wherein Xaa is a D-amino acid and G is selected from the following three groups:The compounds are useful in the prophylaxis and treatment of pain, pruritis and inflammation associated with a variety of diseases and conditions.
