Guangcheng Jiang;Roberta Vezza Alexander;Derek T. Chalmers;Zhiyong Luo;Frederique Menzaghi;Javier Sueiras-Diaz;Claudio D. Schteingart;Robert H. Spencer
发明人:
Claudio D. Schteingart,Frederique Menzaghi,Guangcheng Jiang,Roberta Vezza Alexander,Javier Sueiras-Diaz,Robert H. Spencer,Derek T. Chalmers,Zhiyong Luo
申请号：
US12480059
公开号：
US08236766B2
申请日:
2009.06.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to synthetic peptide amides that are ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure:wherein Xaa is a D-amino acid and G is selected from the following three groups:The compounds are useful in the prophylaxis and treatment of pain, pruritus and inflammation associated with a variety of diseases and conditions.
