Claudio D. Schteingart,Frédérique Menzaghi,Guangcheng Jiang,Roberta Vezza Alexander,Javier Sueiras-Diaz,Robert H. Spencer,Derek T. Chalmers,Robert Zhiyong Luo
申请号：
US16199308
公开号：
US20190241610A1
申请日:
2018.11.26
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure of formula I:These compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions.
