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Amniotic Membrane inmunocompatibles Products
专利权人:
OSIRIS THERAPEUTICS; INC.
发明人:
MARCONI, JENNIFER MICHELLE,JANSEN, TIMOTHY,TOM, SAMSON,DANILKOVITCH, ALLA,YOO, DANA,KUANG, JIN-QIANG
申请号:
ARP110100508
公开号:
AR080221A1
申请日:
2011.02.18
申请国别(地区):
AR
年份:
2012
代理人:
摘要:
Placenta products, including immunopreservative films. These placental products can be screened after thawing and contain feasible treatment cards. Placenta products are now useful tools for promoting healing. Item 1: a method for producing placenta products, characterized by the following steps: A. obtaining placenta; B. selectively eliminating one or more major parts of one or more immune cells in amniotic membrane, including large cells CD14 + function;And selective removal procedures maintain the feasibility of a large part of local treatment cells, selected from Morgan Stanley Capital International, fibers, epithelial cells or combinations of the above; C. screening amniotic membrane in low temperature environment; D. optional,2. A large number of vascular tissues or immune cells were removed from the placenta or the related amniotic membrane. Second requirement: the method of the first requirement, which is characterized in that this elimination step includes removing obstacles of corionica membrane and retaining corionica membrane. ILO Convention No. 4: ILO Convention No. 1, characterized by the selective elimination or non use of the CD14 + function macro. Requirement 5: method of requirement 4,characterized in that said elimination step comprises cooling the placenta for a certain period of time before the cryopreservation step. Claim 8: The method of claim 5, characterized in that said period of time is at least about 10 minutes, about 20 minutes, about 30 minutes, about 40 minutes or about 50 minutes. Claim 10: The method of any of claims 5-9, characterized in that the cooling comprises incubating the placenta during said period of time at a temperature between about -10 ° C and about 15 ° C,o de aproximadamente 2 -8 C Reivindicacion 11 El m todo de la reivindicacion 4 caracterizado porque dicho paso de eliminacion comprende tratar la placenta con un anticuerpo anti-TNF-alfa Reivindicacion 13 El m todo de cualquiera de las reivindicaciones precedentes car
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