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TRIPLE FACTORS (TFF) FOR TREATMENT OF CHRONIC LUNG DISEASES
专利权人:
ТРИФОЙЛИУМ АпС (DK)
发明人:
ФИАЛА Коре (DK),ХЕСЛЕТ Ларс (DK)
申请号:
RU2012156256/15
公开号:
RU2012156256A
申请日:
2011.06.03
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A composition comprising one or more progenerative factors for use as a medicament for enhancing the repair and / or regeneration of the airway epithelium and / or normalizing remodeling of the airway epithelium in the terminal lung element (TLU), interalveolar septum, lung interstitium and lung parenchyma .2. The composition of claim 1, wherein an effective amount of one or more progenerative factors is administered to the individual by pulmonary administration such as intratracheal, intrabronchial, intraalveolar or bronchoalveolar administration. The composition according to claim 1, where the pro-regenerative factor is a peptide or protein from the family of factors of the trefoil family (TFF) or its variant. The composition of claim 1, wherein the pro-regenerative factor is a dimer of a peptide of a family of trefoil family factors (TFF). The composition according to claim 1, where the pro-regenerative factor is a factor of the trefoil family 3 (TFF3) or its variant, derivative or analogue. The composition of claim 1, wherein the pro-regenerative factor is a dimer of a factor of the trefoil family 3 (TFF3). The composition of claim 1, wherein the individual has a chronic lung condition. The composition of claim 1, wherein the individual in need of treatment suffers from a chronic condition of the respiratory tract selected from the group consisting of asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, cystic fibrosis, bronchiectasis, panbronchiolitis, lung cancer, pneumonia, ventilator-associated pneumonia (VAP), hospital pneumonia (NAP), community-acquired pneumonia (CAP), severe community-acquired1. Композиция, содержащая один или несколько прорегенеративных факторов для применения в качестве лекарственного средства для усиления репарации и/или регенерации эпителия дыхательных путей и/или нормализации ремоделирования эпителия дыхательных путей в терминальном элементе легкого (TLU), межальвеолярной перегородке, интерстиции легкого и па
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