The present invention provides a use of Imperata cylindrica fermented extracts in a composition for regulating the expression of LDLR gene, ABCA1 gene, PTGIS gene, SERPINE1 gene and IGF2BP3 gene, so as to effectively increase the metabolism of LDL and to promote the production of HDL, in order to maintain the balance of LDL and HDL in the blood, and also to effectively prevent thrombosis and vasodilatation, and to reduce the occurrence of cardiovascular diseases such as obesity and diabetes. The Imperata cylindrica fermented extracts is prepared by fermenting the Imperata cylindrica extracts to yeast, lactic acid bacteria and acetic acid bacteria for three-stage fermentation.本發明提供一種白茅根發酵物用於調控LDLR基因、ABCA1基因、PTGIS基因、SERPINE1基因及IGF2BP3基因表現量之組合物的用途，能有效增加低密度脂蛋白的代謝及促進高密度脂蛋白的生成，以維持血液中LDL與HDL之平衡，亦能有效預防血栓形成與舒張血管，並降低肥胖與糖尿病等相關心血管疾病之發生。其中該白茅根發酵物，係將白茅根水萃取物以酵母菌、乳酸桿菌及醋酸桿菌進行三段式發酵所製得。
