Gordeeva Olga Borisovna (RU),Гордеева Ольга Борисовна (RU),Basargina Elena Nikolaevna (RU),Басаргина Елена Николаевна (RU),Babajkina Marina Anatolevna (RU),Бабайкина Марина Анатольевна (RU),Vashakmadz
申请号：
RU2019118240
公开号：
RU0002719909C1
申请日:
2019.06.13
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to biochemical pharmacology, and can be used to select an effective dose of beta-adrenergic blocking agents - BAB in cardiomyopathies in children. Thrombocyte aggregation is evaluated. Thrombocyte aggregation is analysed in whole blood by an impedance method in a cuvette with electrodes； the aggregation inducers used are soluble activators of thrombin receptors - TRAP-reagent and collagen - COL-reagent. Area under the aggregatogram curve is evaluated. Rate of thrombocyte aggregation is assessed on the instrument screen, by the aggregation curve and area under curve U, which is calculated automatically. If the TRAP-test values are within range of 62.0–86.0 U, and the COL-test is within range of 16.5–36.0 U, measured on 14th day of the BAB therapy, the dose of the BAB is considered to be effective. If TRAP- and COL-tests exceed the boundaries of these intervals, the selected dose of BAB is considered to be ineffective, requiring correction with subsequent evaluation of the aggregation curve in dynamics.EFFECT: method provides the possibility of correcting a dose of BAB if necessary, which enables a timely assessment of the degree of patient's sensitivity to a certain preparation and dose thereof, by evaluating the aggregation function of thrombocytes by the value of the tests with underlying BAB.1 cl, 2 exИзобретение относится к медицине, а именно к биохимической фармакологии, и может быть использовано для подбора эффективной дозы бета-адреноблокаторов - БАБ при кардиомиопатиях у детей. Проводят определение агрегационной способности тромбоцитов. Проводят исследование агрегации тромбоцитов в цельной крови импедансным методом в кювете с электродами, в качестве индукторов агрегации используют растворимые активаторы рецепторов тромбина - TRAP-реагент и коллагена - COL-реагент. Проводят оценку площади под кривой агрегатограммы. Скорость агрегации тромбоцитов оценивают на экране прибора, по кривой агрегации и п
