Joel C. Higgins,James M. McKale,Jennifer E. Woodell-May
申请号：
US13392266
公开号：
US09763875B2
申请日:
2010.08.27
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Treatments and devices for generating and using interleukin-1 receptor antagonist (IL-1ra). An implantable device is loaded with adipose tissue and/or white blood cells and inserted into an inflammation site in a patient to produce interleukin-1 receptor antagonist in vivo. The implantable device has an enclosed or substantially enclosed body that defines an internal space. At least a portion of the body comprises a first bioresorbable material and a second bioresorbable material is within the internal space along with one or more voids. The second bioresorbable material includes an activation surface to activate adipose tissue and/or white blood cells loaded into the device to produce IL-1ra.
