ALMUDENA RUBIO,BRADLEY EARL REAMAN,DANIEL JON SALL,GAIYING ZHAO,JAMES ROBERT HENRY,JEFFREY DANIEL COHEN,JIEHAO CHEN,JOLIE ANNE BASTIAN,WILLIAM THOMAS MCMILLEN
申请号：
BR112018072872
公开号：
BR112018072872A2
申请日:
2017.05.31
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
the present invention relates to certain novel 2,3-dihydro-1h-indole compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer selected from the group consisting of melanoma, acute myeloid leukemia, chronic lymphocytic leukemia, colorectal cancer, breast cancer, lung cancer, Ovary cancer, fallopian tube carcinoma, primary peritoneal carcinoma, cervical cancer, gastric cancer, liver cancer, pancreatic cancer, thyroid cancer, glioblastoma, non-hodgkin's lymphoma and hodgkin's lymphoma.a presente invenção refere-se a certos novos compostos de 2,3-di-hidro-1h-indol, composições farmacêuticas compreendendo os compostos, e métodos de uso dos compostos para tratar câncer, mais particularmente para o tratamento de câncer selecionado a partir do grupo consistindo em melanoma, leucemia mieloide aguda, leucemia linfocítica crônica, câncer colorretal, câncer de mama, câncer de pulmão, câncer de ovário, carcinoma das trompas de falópio, carcinoma peritoneal primário, câncer cervical, câncer gástrico, câncer de fígado, câncer pancreático, câncer de tireoide, glioblastoma, linfoma não hodgkin e linfoma de hodgkin.
