DERIVADOS DE 8-CARBAMOÍL-2-(PIRID-6-IL 2,3-DISSUBSTITUÍDO)-1,2,3,4-TETRA-HIDROISOQUINOLINA COMO AGENTES INDUTORES DA APOPTOSE, PARA O TRATAMENTO DE CANCRO E DOENÇAS IMUNES E AUTOIMUNES
AARON R.KUNZER,XIAOHONG SONG,ANDREW J. SOUERS,WANG, LE,XILU WANG,TODD M.HANSEN,GEORGE DOHERTY,ZHI-FU TAO,MILAN BRUNKO,MICHAEL D. WENDT,ROBIN FREY,ANDREW JUDD,GERARD M. SULLIVAN
申请号：
PT12780605
公开号：
PT2766361T
申请日:
2012.10.11
申请国别(地区):
PT
年份:
2016
代理人:
摘要：
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which Bcl-xL proteins are expressed, eg cancer. X is heteroaryl； Y1 is phenylene or heteroarylene； L1 is a linker； Y2 is cycloalkyi, cycloalkenyl, heterocycloalkyl or heterocycloalkenyl； Z1 is C(0)OR9, C(O)NR10R11, C(0)R11, NR10C(O)R11, etc.
