A hygienic toothbrush maintenance system helps maintain a toothbrush in a hygienic state through use of at least one detachable head that can be interchanged, and ultraviolet light that immerses bristles to kill bacteria. A pair of tensioned wires on the detachable head slides in and out of a head end of the toothbrush to enable secure and easy detachable attachment of the detachable head from the toothbrush. A release switch enables detachment of the detachable head from the toothbrush, and is operable with one hand so as to minimize contact with the toothbrush. A docking platform retains the toothbrush in an upright position and stores the removed detachable heads. An ultraviolet portion includes a telescopically extendable stand and a hood that emits ultraviolet light. The hood pivots to substantially cover the detachable heads, while they are attached to the toothbrush, and while stored in a head reception portion.